Diet & Movement Disorders, Tics,
Tourette Syndrome
Home ||| Research Menu Page ||| Last update 4/21/2008
Listed in reverse date order:
| Lau 2006 | Synergistic Interactions Between Commonly Used Food Additives in a Developmental Neurotoxicity Test. |
| Gerrard 1994 | Neuropharmacological evaluation of movement disorders that are adverse reactions to specific foods. |
| Wurtman 1992 | Effects of foods on the brain. Possible implications for understanding and treating Tourette syndrome. |
| Augustine 1980 | Neurotransmitter Release from a Vertebrate Neuromuscular Synapse Affected by a Food Dye. |
| Levitan 1977 | Food, drug, and cosmetic dyes: Biological effects related to lipid solubility. |
Note: Many parents report that the Feingold diet consistently improves or controls Tourette Syndrome. We are still waiting for the research to show WHY this happens.
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This is a book worth reading, by Sheila Rogers of the Association for Comprehensive NeuroTherapy. Click on the picture to order through the Feingold Bookstore, or see the ACN website for more information.
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No Abstract
"...FD&C No.3 ... produced an irreversible, dose-dependent increase in neurotransmitter release ... These results suggest that erythrosine might prove a useful pharmacological tool for studying the process of transmitter release, but that its use as a food additive should be re-examined."
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"Three cases are reported of patients who had episodic movement disorders triggered by foods or components of the diet. [aspartame was one] ... These observations suggest that, in susceptible individuals, foods can trigger movement disorders through an action on dopamine and other neurotransmitter pathways in the brain."
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Exposure to non-nutritional food additives during the critical development window has been implicated in the induction and severity of behavioural disorders such as attention deficit hyperactivity disorder (ADHD). . . We therefore examined the neurotoxic effects of four common food additives in combinations of two (Brilliant Blue and L-glutamic acid, Quinoline Yellow and aspartame) to assess potential interactions. . . Neurotoxicity was measured as an inhibition of neurite outgrowth. . . . Theoretical exposure to additives was calculated based on analysis of content in foodstuff, and estimated percentage absorption from the gut. Inhibition of neurite outgrowth was found at concentrations of additives theoretically achievable in plasma by ingestion of a typical snack and drink. . . both combinations had a straightforward additive effect on cytotoxicity. These data have implications for the cellular effects of common chemical entities ingested individually and in combination.
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Full text of study
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"The synthetic coloring agents increased the resting membrane
potential and conductance of the neurons in a dose-dependent manner by
increasing the potassium permeability of the membrane relative to that of
other ions."
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Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139.
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