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Diet & Allergy
Research Menu Page ||| Last update 11/18/2013

Listed in reverse date order:

Zugasti 2009 Food Intolerance.
Bhatia 1996 Allergy to tartrazine in alprazolam.
Jimenez-Aranda 1996     Prevalence of chronic urticaria following the ingestion of food additives in a third tier hospital.
Lucarelli 1995 Food allergy and infantile autism.
Schapowal 1995 Phenomenology, pathogenesis, diagnosis and treatment of aspirin-sensitive rhinosinusitis.
Nsouli 1994 Role of Food Allergy in Serous Otitis Media.
Allen 1984 Adverse reactions to foods.
Wilson 1983 Recurrent acute otitis media in infants--role of immune complexes acquired in utero.
Neuman 1978    The danger of "yellow dyes" (tartrazine) to allergic subjects.


The following excerpts are in alphabetical order by first author.


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  1. Adverse reactions to foods. Allen DH, Van Nunen S, Loblay R, Clarke L, Swain A, Med J Aust 1984 Sep 1;141(5 Suppl):S37-42
    "... This, [discovery of IgE in the 1960's] ... has resulted in considerable confusion in the minds of both the public and the medical profession on the subject. In the majority of patients presenting with food intolerance, recognized or otherwise, symptoms are precipitated by various small, non-immunogenic organic molecules present in the food as natural or added ingredients. These reactions are pharmacological rather than immunological in nature, although in some situations ... resulting in similar symptoms."
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  2. Allergy to tartrazine in alprazolam. Bhatia MS, Indian J Med Sci 1996 Aug;50(8):285-6
    "Allergy to tartrazine-containing psychotropic medication (especially antidepressants) had been reported. 20 patients of apparent allergy to tartrazine-containing alprazolam brands in 480 patients exposed to the dye are described. Rechallenge with non tartrazine-containing alprazolam brands did not produce the similar allergic reactions."
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  3. Prevalence of chronic urticaria following the ingestion of food additives in a third tier hospital Jimenez-Aranda GS, Flores-Sandoval G, Gomez-Vera J, Orea-Solano M, Rev Alerg Mex 1996 Nov-Dec;43(6):152-6
    " We studied 40 patients with the clinical diagnostic of chronic urticaria from January to June, 1995 ... We performed a basic clinics history and the oral challenge tests (PRO) included Tartrazine (Ta), Sodium Metabisulfite (MS), Potasium Metabisulfite (MP) and Sodium Bisulfite (BS) in consecutive days with increasing doses unless an adverse reactions appear. ... 63.8% (23/36) had positive PRO. 47.2% (17/36) positives to Ta,, 36.1% (13/36) to MS, 33.3% (12/36) to BS and 30.5% (11/36) to MP. 72.2% (26/36) had positive PC [skin prick test] to one or more foods, 65.3% (17/26) besides had positive PRO. 41.1% (7/17) of the patients who had positive PRO and positive PC to foods had sinusitis. .... Ta was the additive that cause more reactivity. It is possible to find reactivity to one or more additives in a patient with chronic urticaria."
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  4. Food allergy and infantile autism. Lucarelli S, et al., Panminerva Med 1995 Sep;37(3):137-41
    "...We noticed a marked improvement in the behavioural symptoms of patients after a period of 8 weeks on an elimination diet ... Our results lead us to hypothesise a relationship between food allergy and infantile autism as has already been suggested for other disturbances of the central nervous system."
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  5. The danger of "yellow dyes" (tartrazine) to allergic subjects. Neuman I, Elian R, Nahum H, Shaked P, Creter D. Clin Allergy. 1978 Jan;8(1):65-8.
    " Oral administration of 50 mg tartrazine to 122 patients with a variety of allergic disorders caused the following reactions: general weakness, heatwaves, palpitations, blurred vision, rhinorrhoea, feeling of suffocation, pruritus and urticaria. There was activation of the fibrinolytic pathway . . ."
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  6. Role of Food Allergy in Serous Otitis Media., Nsouli TM, Nsouli SM, Linde RE, O'Mara F, Scanlon RT, Bellanti JA. Annals of Allergy 1994 Sep;73(3):215-9
    There was a significant association between food allergy and repeated earaches (recurrent serous otitis media) in 81/104 patients (78%). "The elimination diet led to a significant amelioration of serous otitis media in 70/81 (86%) patients as assessed by clinical evaluation and tympanometry. The challenge diet with the suspected offending food(s) provoked a recurrence of serous otitis media in 66/70 patients (94%). CONCLUSIONS. The possibility of food allergy should be considered in all pediatric patients with recurrent serous otitis media and a diligent search for the putative food allergen made for proper diagnostic and therapeutic intervention."
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  7. Phenomenology, pathogenesis, diagnosis and treatment of aspirin-sensitive rhinosinusitis. Schapowal AG, Simon HU, Schmitz-Schumann M, Acta Otorhinolaryngol Belg 1995;49(3):235-50
    "Aspirin-sensitive rhinosinusitis is a non-allergic, non-infectious perennial eosinophilic rhinitis starting in middle age and rarely seen in children. ... There is an intolerance to aspirin and most other NSAID. An intolerance to tartrazine, food additives, alcohol, narcotics and local anaesthetics can follow. Most aspirin-sensitive patients develop nasal polyps. Untreated, it can lead to asthma. The frequency of aspirin intolerance is 6.18% in patients with perennial rhinitis and 14.68% in patients with nasal polyps. ... "
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  8. Recurrent acute otitis media in infants--role of immune complexes acquired in utero. Wilson WH, Laryngoscope 1983 Apr;93(4):418-21
    "Ten infants experiencing recurring episodes of acute otitis media with associated otitis media with effusion while on human breast milk afford a study of the role of possible immune complexes acquired in utero through the mother's allergic diathesis. ... Challenge feeding tests determined the mothers' hypersensitivities. Those infants breast fed by mothers exhibiting positive challenges to specific foods, manifest allergic responses themselves following the first breast feeding after the mothers' challenge. A cessation of episodes ... occurred in five ... as foods proven to be offenders were eliminated from the mother's and child's diet..."
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  9. Food Intolerance. Zugasti Murillo A., Endocrinologia y Nutricion. 2009 May;56(5):241-50. Epub 2009 Jul 1.
    " Adverse food reactions are common in the general population. Nevertheless, our knowledge of the structure of food allergens and of the mechanisms involved is poor. In 1995 the European Academy of Allergology and Clinical Immunology suggested a classification based on the causative pathogenic mechanism. According to this classification, non-toxic reactions can be divided into food allergies when they recognize immunological mechanisms and food intolerance when there are no immunological implications. The treatment of food intolerance is avoidance of the particular food. There are specific treatments for some food intolerance (beta-galactosidases for the management of lactose intolerance)."
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