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G6PD Enzyme Deficiency


Research Menu Page ||| Last update 02/23/2004

Listed in reverse date order:
el-Saadany 1991Biochemical effect of chocolate colouring and flavouring like substances on thyroid function and protein biosynthesis.
Williams 1988Haemolytic anaemia associated with Nigerian barbecued meat (red suya).
Worathumrong 1975     The effect of o-salicylate upon pentose phosphate pathway activity in normal and G6PD-deficient red cells.



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  1. Biochemical effect of chocolate colouring and flavouring like substances on thyroid function and protein biosynthesis. el-Saadany SS, Nahrung 1991;35(4):335-43
    "Synthetic chocolate colourant, flavourant and the mixture of both were administered to healthy adult male albino rats to evaluate their effect on the nucleic acids metabolism,... total serum protein, thyroid hormones (T4 and T3) and nuclease enzymes, ... in brain, liver, and kidneys. Also, the activity of the fundamental enzymes ... (G-6-PD and 6-PGD), as well as total lipids and cholesterol contents in the same organs were studied. Ingestion of the studied food additives significantly increased serum protein, RNA and T4 hormone, while, DNA and T3 hormone were insignificantly elevated. In connection with this, the hydrolytic enzymes of nucleic acids... were stimulated by all studied food additives and in all mentioned organs. The activity of G-6-PD and 6-PGD ... increased. The highest increase was noticed in rats fed on diets supplemented with the mixture of both colourant and flavourant followed by colourant then flavourant, respectively."
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  2. Haemolytic anaemia associated with Nigerian barbecued meat (red suya). Williams CK, Osotimehin BO, Ogunmola GB, Awotedu AA, Afr J Med Med Sci 1988 Jun;17(2):71-5
    Five cases of haemolytic anaemia occurring in male Nigerians following the ingestion of spiced barbecued meat ... a special brand, called red suya... Ingestion of the culprit suya sample was followed within 24 h by malaise and fever, while passage of dark-coloured urine and jaundice followed 1-3 days thereafter. ... G6PD deficiency was a predisposing factor ... the culprit agent responsible for the haemolytic disease is believed to be a recently introduced food additive that is probably accessible only to a limited number of suya vendors.
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  3. The effect of o-salicylate upon pentose phosphate pathway activity in normal and G6PD-deficient red cells. Worathumrong N, Grimes AJ Br J Haematol 1975 Jun;30(2):225-31
    The effect of the major metabolite of aspirin, namely salicylic acid, upon the pentose phosphate pathway (PPP) of normal and G6PD-deficient red cells has been studied. Salicylic acid was shown to inhibit this pathway in proportion to the amount present. At any concentration of this substance there was greater inhibition of the PPP in G6PD-deficient than in normal red cells.
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