Home ||| Research Menu Page ||| Updated 6/4/06Some Early Research on Food Additives, Salicylates
Arranged by date, beginning with the earliest
& Chemical Pollutants -- 1945-1975The effect of salicylates on the electrolyte structure of the blood plasma. I. Respiratory alkalosis in monkeys and dogs after sodium and methyl salicylate; The influence of hypnotic drugs and of sodium bicarbonate on salicylate poisoning. Rapoport S, Guest, GM The Journal of Clinical Investigation, 1945 September; 24(5): 759–769 (FULL TEXT)
The effect of salicylates on the electrolyte structure of the blood plasma. II. The action of therapeutic doses of sodium salicylate and of acetylsalicylic acid in Man. Guest, GM; Rapoport, S; Roscoe C, The Journal of Clinical Investigation. 1945 September; 24(5): 770–774. (FULL TEXT)
Summary: In the plasma of patients receiving therapeutic doses of sodium salicylate or of acetylsalicylic acid, decreased tension and content of CO2, and small changes of pH were found. The plasma chloride was usually elevated, and the sodium was occasionally decreased. The effect of salicylate appeared to be proportional to the dose administered and to increase with the period of medication. The results indicate that salicylates produce primary hyperpnea (abnormally deep or rapid breathing) with consequent decrease of CO2 tension. Various types of adjustment of the electrolyte equilibrium to the hyperventilation were observed.Allergic reactions due to F D and C Yellow No. 5, tartrazine, an aniline dye used as a coloring and identifying agent in various steroids. LOCKEY SD, Annals of Allergy 1959 Sept-Oct;17:719-21Birch pollen and aspirin psoriasis. A study in salicylate hypersensitivity. Shelley WB, JAMA 1964 Sep 28;189:985-8
(FULL TEXT) Coloring materials and chemical additives in foods (Article in Italian), Angelini A, Arch Vet Ital 1965 Jun 30;16(3):167-75
Food additives and public health, (Article in French), Jeanneret O, Z Praventivmed 1965 Jul-Aug;10(4):295-311
Food additives, their toxicity and their significance for human nutrition (Article in German), Marquardt P, Hippokrates 1965 Jul 31;36(14):539-43
Food allergodermatoses (Article in Italian), Ottolenghi F, Minerva Med 1966 May 5;57(36):1613-4
Nutritional impact of modern food processing. Campbell JA, Morrison AB, Fed Proc 1966 Jan-Feb;25(1):130-6
Nutritional significance of the non-nutrient components of food. Introductory remarks. Friedman L, Fed Proc 1966 Jan-Feb;25(1):102-3
Chemical additives in foods. (Article in Italian), D'Ambrosio A, Minerva Med 1966 May 5;57(36):1607-8
Early changes at the site of repeated subcutaneous injection of food colourings. Grasso P, Golberg L, Food Cosmet Toxicol 1966 Jun;4(3):269-82
Health aspects of food additives. Johnson PE, Am J Public Health Nations Health 1966 Jun;56(6):948-51
SUMMARY Biological effects of Citrus Red No. 2 in the mouse. Sharratt M, Frazer AC, Paranjoti IS, Food Cosmet Toxicol 1966 Oct;4(5):493-502
Effect of salicylates in urticaria. Moore-Robinson M, Warin RP, Br Med J 1967 Nov 4;4(574):262-4
Physical factors determining the early local tissue reactions produced by food colourings and other compounds injected subcutaneously. Gangolli SD, Grasso P, Golberg L, Food Cosmet Toxicol 1967 Nov;5(5):601-21
Asthma caused by FD&C approved dyes. Chafee FH, Settipane GA, J Allergy 1967 Aug;40(2):65-72
Gastrointestinal allergy, (Article in Romanian) Sparchez T, Oproiu A, Med Interna (Bucur) 1968 Nov;20(11):1283-9
Food additives and nutrition: a primer. Mayer J, Postgrad Med 1969 Dec;46(6):195-7
Food additives. Chapman DG, Can J Public Health 1970 Sep-Oct;61(5):391-5
Food additives and food adulteration (Article in Japanese), Haruta M, Kango Kyoshitsu 1970 Feb;14(2):16-9
Food additives (Article in Japanese), Hokenfu Zasshi 1970 Dec;26(12):62-3
Food additives. Sittner MA, Occup Health Nurs 1970 Nov;18(11):20-1
Unsolicited food additives. Spodlick DH, New England Journal of Medicine 1970 Dec 17;283(25):1412-3
LETTER to Ed The question of food additives. Ahrens RA, Sch Health Rev 1970 Nov;1(4):19-23
The problem of food additives. DiPalma JR, RN 1970 Jun;33(6):53-62
Food additives. Definition of "food"--for better understanding of food additives (Article in Japanese), Aiiso F, Kango Kyoshitsu 1971 Oct;15(10):14-9
Food additives as a health-destroying factor, Gunji T, Kango Kyoshitsu 1971 Oct;15(10):20-5
Effect of selected antioxidants, dyes and artificial sweetening agents on metabolic processes of animal cells in vitro. II. Effect of dyes and artificial sweetening agents (Article in Polish), Kugaczewska MM, Krauze S, Rocz Panstw Zakl Hig 1972;23(2):165-71
Lung damage in mice following intraperitoneal injection of butylated hydroxytoluene. Marino AA, Mitchell JT. Proc Soc Exp Biol Med 1972 May;140(1):122-5
Effect of some antioxidants, dyes and artificial dulcifying materials on the metabolic processes of animal cells in vitro (Article in Polish), Kugaczewska MM, Krauze S, Rocz Panstw Zakl Hig 1972;23(1):107-16
Food additives--for or against? (Article in Swedish), Linder O, Lakartidningen 1972 Nov 8;69(46):5274-5
Food additives. Lancet 1972 Apr 22;1(7756):887
FULL TEXT Food additives. A possible reason for drug complications-adverse effects? (Article in Norwegian), Lokken P, Lunde PK, Tidsskr Nor Laegeforen 1972 Aug 30;92(24):1541-3
The skin and chemical additives to foods. Schorr WF, Arch Dermatol 1972 Jan;105(1):131
Advantages and disadvantages of food additives, (Article in Japanese), Tanimura A, Josanpu Zasshi 1973 Sep;27(9):26-9
Urticaria induced by preservatives and dye additives in food and drugs. Michaelsson G, Juhlin L, Br J Dermatol 1973 Jun;88(6):525-32
Toxic hazards of foods--additives in children (Article in Spanish), Bosch Perez AV, Folia Clin Int (Barc) 1973 Jul-Aug;23(7):497-506
Prohibitions and permissions in hypersensitivity to preservatives and coloring agents (Article in Swedish), Juhlin L, Michaelsson G, Lakartidningen 1973 Apr 4;70(14):1414-7
Urticaria provoked by preservatives and coloring agents in food and drugs Juhlin L, Michaelsson G, Lakartidningen 1973 Apr 4;70(14):1411-3
Chemical intolerance to butylated-hydroxyanisole (BHA) and butylated-hydroxytoluene (BHT) and vascular response as an indicator and monitor of drug intolerance. Fisherman EW, Cohen G, Annals of Allergy 1973 Mar;31(3):126-33
The effect of butylated hydroxyanisole and butylated hydroxytoluene on behavioral development of mice. Stokes JD, Scudder CL, Dev Psychobiol 1974 Jul;7(4):343-50
TEXT Allergic reactions in asthmatics caused by salicylates and food additives (Article in Finnish), Stenius B, Duodecim 1974;90(23):1643-6
Cutaneous reactions to food and drug additives. Levantine A, Almeyda J, Br J Dermatol 1974 Sep;91(3):359-62
The susceptibility of the fetus and child to chemical pollutants. Behavioral implications of prenatal and early postnatal exposure to chemical pollutants. Weiss B, Spyker JM, Pediatrics 1974 May;53(5):851-9
EXCERPT Food additives and intestinal microflora. Walker R, J Sci Food Agric 1974 Feb;25(2):228-9
Food additives: AF2 (Article in Japanese), Miyaji T, Nippon Rinsho 1974 Mar;32(3):616-7
Aspirin intolerance. III. Subtypes, familial occurence, and cross-reactivity with tartarazine. Settipane GA, Pudupakkam RK, J Allergy Clin Immunol 1975 Sep;56(3):215-21
" Evidence has been presented supporting the hypothesis that at least 2 different types of mechanisms may be involved in aspirin intolerance, one resulting in bronchospasm and the other producing urticaria/angioedema. . . . In a double-blind, crossover study with normal control subjects matched by age and sex 15% (6/40) of aspirin-intolerant individuals had significant adverse reactions to tartrazine challenge and not to the placebo. None of the 40 normal control subjects had any adverse reactions. "