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Some Research on Vaccinations
and ADHD, Autism, Asthma

Home ||| Research Menu Page ||| Last update 2/17/12

In reverse date order:

Geier 2010 Thimerosal exposure & increasing trends of premature puberty in the vaccine safety datalink.
Young 2008 Thimerosal exposure in infants and neurodevelopmental disorders: An assessment of computerized medical records in the Vaccine Safety Datalink.
Ram 2008 Hepatitis B: Infection, Vaccination and Autoimmunity
Mutter 2005 Mercury and autism: Accelerating Evidence?
Mutter 2005 Amalgam risk assessment with coverage of references up to 2005 (Review)
Dias-Tosta 2004 Neurological morbidity in vaccine-associated paralytic poliomyelitis in Brazil from 1989 up to 1995.
Andrews 2004 Thimerosal Exposure in Infants and Developmental Disorders: A Retrospective Cohort Study in the United Kingdom Does Not Support a Causal Association
Heron 2004 Thimerosal exposure in infants and developmental disorders: a prospective cohort study in the United kingdom does not support a causal association.
Tisher 2004 Vaccination may be associated with autoimmune diseases.
Bernard 2002 The role of mercury in the pathogenesis of autism.
Guis 2002 HLA-DRB1*01 and macrophagic myofasciitis.
Yazbak 2002 Live virus vaccination near a pregnancy: flawed policies, tragic results.
Brown 2001 Theoretical estimation of blood mercury levels from Thimerosal injections using a one compartment biokinetic model.
Gherardi 2001 Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminium hydroxide in muscle.
De Oliveira 2000 Vaccine-associated paralytic poliomyelitis: a retrospective cohort study of acute flaccid paralyses in Brazil.
DuVernoy 2000 Hypotonic-Hyporesponsive Episodes Reported to the Vaccine Adverse Event Reporting System (VAERS) 1996-1998.
Megson 2000 Presentation to House Government Reform Committee on Autism and Vaccines.
Yoneyama 2000 The effect of DPT and BCG vaccinations on atopic disorders.



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  1. Thimerosal exposure in infants and developmental disorders: a retrospective cohort study in the United kingdom does not support a causal association., Andrews N, Miller E, Grant A, Stowe J, Osborne V, Taylor B., Pediatrics. 2004 Sep;114(3):584-91.
    " CONCLUSIONS: With the possible exception of tics, there was no evidence that thimerosal exposure via DTP/DT vaccines causes neurodevelopmental disorders."
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  2. The role of mercury in the pathogenesis of autism., Bernard S, Enayati A, Roger H, Binstock T, Redwood L., Mol Psychiatry. 2002;7 Suppl 2:S42-3.
    " These findings support a hypothesis that mercury in vaccines may be a factor in the pathogenesis of autism. Understanding of the underlying biological mechanisms of thimerosal toxicity in populations genetically susceptible to mercury’s effects might lead to effective medical treatments for autistic individuals."
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  3. Full text: - (get password)
    Theoretical estimation of blood mercury levels from Thimerosal injections using a one compartment biokinetic model, Brown, D, IOM Meeting on Thimerosal and Vaccines
    " While the estimates of exposure from Thimerosal do not exceed these risk predictions they are in the same range and, with additivity from other sources, may contribute to an elevated mercury approaching these levels. The National Research Council in 2000 expert panel reviewed the available studies of mercury exposure and toxic outcomes and suggested a BMDL of 58 ppb Hg in cord blood ( corresponding to 12 ppm in maternal hair). These levels are also in the same order of magnitude estimated in this probe study. There is a notably relatively low margin of safety for mercury in the current studies and recommendations. 1. Because the estimated levels of mercury in blood and hair after Thimerosal are in the same order of magnitude as those levels which induce toxic actions in humans with accidental exposures, it is important to obtain a more detailed kinetic analysis using more exact transfer factors and a more complete model. 2. Additivity with other mercury exposures such as fish is a serious possibility and requires caution and re-enforcement of state mercury consumption advice to parents of young children. 3. Because the risk to children is believed to be as much as 10 times greater than risk to adults, the fact that estimates are slightly below the toxic levels would not be considered evidence of safety."

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  4. Vaccine-associated paralytic poliomyelitis: a retrospective cohort study of acute flaccid paralyses in Brazil, de Oliveira LH, Struchiner CJ., International Journal of Epidemiology, 2000 Aug;29(4):757-63.
    " BACKGROUND: At the present time, in Brazil and other countries in the Americas, the only cases of paralytic poliomyelitis due to poliovirus are caused by vaccine strains. The recognition of possible determinants of vaccine-associated paralytic poliomyelitis (VAPP) by public health surveillance and immunization programmes is relevant to inform the debate on criteria for case definition and vaccination strategies. ... CONCLUSIONS: Cases of AFP (acute flaccid paralysis) who received OPV (oral poliovirus vaccine) between 4 and 40 days before the onset of paralysis and had fever, a prodrome of gastrointestinal symptoms, history of first dose of OPV, isolation of vaccine poliovirus type 2, and young age deserve careful investigation, since they are at increased risk for the condition studied. "

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  5. Neurological morbidity in vaccine-associated paralytic poliomyelitis in Brazil from 1989 up to 1995., Dias-Tosta E, Kückelhaus CS., Arquivos de Neuro-Psiquiatris, 2004 Jun;62(2B):414-20. Epub 2004 Jul 20.
    " We collected 30 cases of vaccine associated paralytic poliomyelitis (VAPP) from 4081 cases of acute flaccid palsies cases notified from 1989 to 1995 to the Brazilian Ministry of Health. . . The clinical pattern in 60 days was: monoplegia (16), paraplegia (6), tetraplegia (5), hemiplegia (2) and triplegia (1). There was no strong relationship between fever, before or after the prodrome period, or the use of intramuscular medication to morbidity. CONCLUSION: if the anti-poliomyelitis strategy adopted in Brazil has lead to the eradication of the poliomyelitis with wild virus infection, the existence of a minimum risk of vaccine-associated poliomyelitis is a matter of concern because there will be a permanent neurological deficit. "

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  6. Hypotonic-hyporesponsive episodes reported to the Vaccine Adverse Event Reporting System (VAERS), 1996-1998., DuVernoy TS, Braun MM, Pediatrics. 2000 Oct;106(4):E52.
    " A hypotonic-hyporesponsive episode (HHE) is the sudden onset of hypotonia, hyporesponsiveness, and pallor or cyanosis that occurs within 48 hours after childhood immunizations. ...OBJECTIVES: To characterize a large number of HHE cases reported to the Vaccine Adverse Event Reporting System (VAERS), to assist clinicians in identifying HHE, and to assist researchers in investigating the risk factors, cause, and pathogenesis of this syndrome. ... RESULTS: There were 215 HHE cases, all nonfatal. ... Nearly all of the children (98.6%) returned to their prevaccination state according to the telephone questionnaire; median time to return was 6 hours (range: 1 minute- 4 months). ... From 1996 to 1998, the number of HHE reports decreased from 99 to 38, when the predominant pertussis vaccine administered to infants changed from whole-cell to acellular. CONCLUSION: This study represents the largest published case series of children with HHE and supports the generally benign, self-limited, nonrecurrent nature of this syndrome. Although HHE has been less frequently reported to VAERS after increased use of DTaP, HHE does occur after the administration of DTaP and other nonpertussis-containing vaccines. ... "

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  7. Thimerosal exposure & increasing trends of premature puberty in the vaccine safety datalink., Geier DA, Young HA, Geier MR., Indian J Med Res. 2010 Apr;131:500-7.
    " ...An association between premature puberty and exposure to Hg from thimerosal-containing vaccines (TCVs) was evaluated in computerized medical records within the Vaccine Safety Datalink (VSD). A total of 278,624 subjects were identified in birth cohorts from 1990-1996. ...

    RESULTS: Significantly increased (P<0.0001) rate ratios were observed for premature puberty for a 100 microg difference in Hg exposure from TCVs in the birth-7 months (rate ratio=5.58) and birth-13 months (rate ratio=6.45) of age exposure windows. By contrast, none of the control outcomes had significantly increased rate ratios with Hg exposure from TCVs... "

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  8. Macrophagic myofasciitis lesions assess long-term persistence of vaccine-derived aluminium hydroxide in muscle., Gherardi RK, Coquet M, Cherin P, Belec L, Moretto P, Dreyfus PA, Pellissier JF, Chariot P, Authier FJ., Brain. 2001 Sep;124(Pt 9):1821-31.
    " Macrophagic myofasciitis (MMF) is an emerging condition of unknown cause, detected in patients with diffuse arthromyalgias and fatigue, and characterized by muscle infiltration by granular periodic acid-Schiff's reagent-positive macrophages and lymphocytes. . . Myalgia onset was subsequent to the vaccination (median 11 months) in 94% of patients. MMF lesion was experimentally reproduced in rats. We conclude that the MMF lesion is secondary to intramuscular injection of aluminium hydroxide-containing vaccines, shows both long-term persistence of aluminium hydroxide and an ongoing local immune reaction, and is detected in patients with systemic symptoms which appeared subsequently to vaccination. "

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  9. HLA-DRB1*01 and macrophagic myofasciitis., Guis S, Pellissier JF, Nicoli F, Reviron D, Mattei JP, Gherardi RK, Pelletier J, Kaplanski G, Figarella-Branger D, Roudier J, Arthritis and Rheumatism. 2002 Sep;46(9):2535-7.
    " Macrophagic myofasciitis (MMF) is a recently described inflammatory muscle disease. Manifestations of MMF may include diffuse myalgias, arthralgias, marked asthenia, muscle weakness, fever, and symptomatic demyelinating central nervous system disorder. A substantial minority of patients have abnormal laboratory findings, such as elevated creatine kinase concentrations, increased erythrocyte sedimentation rate, and myopathic electromyograms . . . Because MMF has been observed in twin sisters, it was suggested that aluminum hydroxyde–containing vaccines may trigger MMF in the context of a particular genetic background. The aim of this study was to analyze whether HLA– DRB1 allele polymorphism might be part of this background. "

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  10. Thimerosal exposure in infants and developmental disorders: a prospective cohort study in the United kingdom does not support a causal association., Heron J, Golding J; ALSPAC Study Team. Pediatrics. 2004 Sep;114(3):577-83.
    Beginning:
    "There is an established link between exposure to mercury and impaired childhood cognitive development and early motor skills."
    Conclusion:
    "We could find no convincing evidence that early exposure to thimerosal had any deleterious effect on neurologic or psychological outcome."

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  11. Full text: Presentation to House Government Reform Committee on Autism and Vaccines, Megson, M, April 6, 2000
    " In the vast majority of these cases, one parent reports night blindness . . . caused by a genetic defect in a G protein, . . . Close to the age of "autistic regression," we add pertussis toxin, which completely disrupts G Alpha signals. The opposite G proteins are on without inhibition . . .

    I think we are staring a disaster in the face that has affected thousands of Americans. . . .

    These children are physically ill, immuno-suppressed with a chronic autoimmune disorder affecting multiple organ systems. Funding to look at etiology of autism, to identify children at risk prior to "autistic regression," and to prevent this disorder is imperative. Implementing vaccine policies that are safe for all children should become our first priority. "




  12. Mercury and autism: Accelerating Evidence?, Mutter J, Naumann J, Schneider R, Walach H, Haley B. Neuro Endocrinol Lett. 2005 Oct;26(5):439-46.
    " Institute for Environmental Medicine and Hospital Epidemiology, University Hospital Freiburg, Germany. joachim.mutter@uniklinik-freiburg.de.

    . . . Recently, it was found that autistic children had a higher mercury exposure during pregnancy due to maternal dental amalgam and thimerosal-containing immunoglobulin shots. It was hypothesized that children with autism have a decreased detoxification capacity due to genetic polymorphism. In vitro, mercury and thimerosal in levels found several days after vaccination inhibit methionine synthetase (MS) by 50%. . . . Repetitive doses of thimerosal leads to neurobehavioral deteriorations in autoimmune susceptible mice, increased oxidative stress and decreased intracellular levels of glutathione in vitro. Subsequently, autistic children have significantly decreased level of reduced glutathione. Promising treatments of autism involve detoxification of mercury, and supplementation of deficient metabolites. "

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  13. Amalgam risk assessment with coverage of references up to 2005 Mutter J, Naumann J, Walach H, Daschner F., Gesundheitswesen. 2005 Mar;67(3):204-16.
    " Institut fur Umweltmedizin und Krankenhaushygiene, Universitatsklinik Freiburg. joachim.mutter@uniklinik-freiburg.de

    . . .Amalgam contributes substantially to human mercury load. Mercury accumulates in some organs, particularly in the brain, where it can bind to protein more tightly than other heavy metals (e. g. lead, cadmium). Therefore, the elimination half time is assumed to be up to 1 - 18 years in the brain and bones. Mercury is assumed to be one of the most toxic non-radioactive elements. . . . Review of recent literature suggests that mercury from dental amalgam may lead to nephrotoxicity, neurobehavioural changes, autoimmunity, oxidative stress, autism, skin and mucosa alterations or non-specific symptoms and complaints. The development of Alzheimer's disease or multiple sclerosis has also been linked to low-dose mercury exposure. There may be individual genetical or acquired susceptibilities for negative effects from dental amalgam. Mercury levels in the blood, urine or other biomarkers do not reflect the mercury load in critical organs. Some studies regarding dental amalgam reveal substantial methodical flaws. Removal of dental amalgam leads to permanent improvement of various chronic complaints in a relevant number of patients in various trials. Summing up, available data suggests that dental amalgam is an unsuitable material for medical, occupational and ecological reasons. "

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  14. Full Text: Hepatitis B: Infection, Vaccination and Autoimmunity. Ram M & Shoenfeld Y Israel Medical Association Journal, 2008, 10: January: 61-64
    " The idea that infectious agents in general, and viruses in particular, could trigger the development of autoimmune diseases in genetically susceptible individuals has been raised in various clinical and epidemiological studies. ... However, there is no conclusive evidence for a causal link between vaccinationand the development of autoimmune diseases since it has not been determined whether available epidemiological tools are sensitive enough to detect such a link. The debate rages on. ... In this review we will summarize the relevant data ragarding HBV and hepatitis B vaccination and their association with autoimmunity. "

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  15. Full Text: Vaccination may be associated with autoimmune diseases. Tishler J & Shoenfeld Y, Israel Medical Association Journal. 2004; 6:430-432.
    " Autoimmune diseases affect as many as 1 in 10 people in Europe and North America... Since some autoimmune disorders arise in age groups that are often selected as target populations for vaccination programs and reports have accuulated on observed side effects following vaccination, this is starting to emerge as a more complex issue than previously thought. "

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  16. Live virus vaccination near a pregnancy: flawed policies, tragic results. Yazbak FE, Yazbak K, Med Hypotheses. 2002 Sep;59(3):283-8.
    " Vaccination of women with live virus vaccines around conception has always been contraindicated by the Center for Disease Control and Prevention (CDC) and the vaccine manufacturer because of potential risks to the fetus. Nevertheless this dangerous practice occurs and is associated with maternal health problems and a very high incidence of early-onset autism in the children.Postpartum vaccination with live virus vaccines has been recommended by the CDC, and described as 'convenient' by the vaccine manufacturer. This 'routine practice' . . .is also associated with many health and obstetrical problems in the recipient, and is frequently associated with autism in both current and future children. Re-vaccination often fails to produce immunity, the very reason for which it was recommended. "

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  17. The effect of DPT and BCG vaccinations on atopic disorders. Yoneyama H, Suzuki M, Fujii K, Odajima Y, Arerugi 2000 Jul;49(7):585-92
    " ...Among the 82 children aged 0-3, out of the 39 who received DPT vaccination, 10 (25.6%) suffered from bronchial asthma and this ratio was significantly higher than among the children who have not received DPT vaccination (1 in 43, 2.3%), ... This was also the case concerning atopic dermatitis (... 18.0% vs ... 2.3%) . ... if ... (bronchial asthma, allergic rhinitis and atopic dermatitis) were combined (... 56.4% vs ... 9.3%) ... From these results, we conclude that DPT vaccination has some effect in the promotion of atopic disorders, ..."

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  18. Thimerosal exposure in infants and neurodevelopmental disorders: An assessment of computerized medical records in the Vaccine Safety Datalink. Young HA, Geier DA, Geier MR., J Neurol Sci. 2008 Aug 15;271(1-2):110-8. Epub 2008 May 15.
    " The study evaluated possible associations between neurodevelopmental disorders (NDs) and exposure to mercury (Hg) from Thimerosal-containing vaccines (TCVs) by examining the automated Vaccine Safety Datalink (VSD). A total of 278,624 subjects were identified in birth cohorts from 1990–1996 that had received their first oral polio vaccination by 3 months of age in the VSD. . . Consistent significantly increased rate ratios were observed for autism, autism spectrum disorders, tics, attention deficit disorder, and emotional disturbances with Hg exposure from TCVs. By contrast, none of the control outcomes had significantly increased rate ratios with Hg exposure from TCVs. Routine childhood vaccination should be continued to help reduce the morbidity and mortality associated with infectious diseases, but efforts should be undertaken to remove Hg from vaccines. ..."

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